![]() We use in vitro reconstitution and cellular biochemistry to understand biosynthetic and regulatory mechanisms at a molecular level, and we use genetics to guide and test our hypotheses. We use antibiotics and small molecule probes discovered in the lab in genome-wide studies that reveal connections between pathways involved in cell growth and division. The bacterial pathogen Staphylococcus aureus is our primary model system, but we venture into other Gram-positive organisms when necessary. We are motivated by both fundamental interest and by the need for new strategies to treat antibiotic-resistant infections. ![]() The lab has two overarching scientific goals (below) and combines core expertise in Biochemistry with chemistry, genetics, proteomics, and genome-wide approaches to attain them.ฤก) We want to understand how cell growth and division are coordinated in bacteria. ![]() We offer talented trainees challenging scientific problems and guide them as they discover solutions. ![]() The purpose of the Walker lab is to foster a collaborative learning environment where graduate students and postdocs thrive as they pursue their goals. ![]()
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